Tuesday, April 26, 2011

A pharma marketing tactic you probably didn't know about

http://www.npr.org/2011/04/26/135703500/supreme-court-weighs-whether-to-limit-data-mining

Apparently the Supreme Court is hearing a case about using physicians' Rx habits to target drug marketing efforts. Retail pharmacies are legally required to keep records of every Rx filled, and then they turn around and sell that info to data mining firms, who in turn sell it to pharmas. This helps pharma sales forces see which doctors need the most persuasion and which products are the biggest threats to theirs. Of course patient info is confidential, but doctor Rx habits are fair game, even if it is very upsetting to some. So recently Vermont outlawed this practice (unless the doctor gives consent), though a pharma trade group sued on First Amendment free access to info grounds, and the case has reached the high court.

Depending on how the case plays out, there could be implications for all the other data mining industries out there (Google, Facebook, etc.).

Friday, April 22, 2011

Is sugar toxic?

http://www.nytimes.com/2011/04/17/magazine/mag-17Sugar-t.html?_r=3&adxnnl=1&ref=homepage&src=me&pagewanted=all&adxnnlx=1303339871-np8HMDjThEJmLpLPzTQSew
http://www.kqed.org/a/forum/R201104211000

Maybe you have heard about this issue, which is part of the health care debate. We know that cardiovascular diseases account for over $400B of medical costs in the US per year, and countless other social harm and externalities (lost productivity, caretaking, etc.). We assume that fatty foods are the problem, and that's part of it, but a UCSF pediatrics researcher (and plenty of others) has concluded that the biggest culprit is actually sugar: natural sugar fructose, or processed sugar sucrose which is fructose+glucose. Many foods can cause us to gain weight, but sugars push us to metabolic syndromes like insulin dysregulation (leading to diabetes, which increases risk or exacerbates all the other inflammatory cardio diseases, which is the leading cause of death in the West).

We know that sugar "rots our teeth" and sweets are a guilty pleasure, but there is very little human data out there comparing high vs. low sugar diets in controlled studies. This is partly because it takes so long and it's hard to keep subjects on a regulated diet. In lab animals, it's pretty darn convincing:

http://www.sciencedaily.com/releases/2008/12/081210090819.htm
http://www.portlandtribune.com/news/story.php?story_id=129728500537306200
http://beavercountyblue.org/2010/09/15/high-fructose-corn-syrup-major-cause-of-obesity/

But fructose exists in nature. It's a part of fresh fruit, which the diet experts say are good, right? But in nature, most high-fructose foods also contain a large amount of fiber, which negates the negative effects of fructose. High-fructose corn syrup is all sugar with no fiber, and it's practically everywhere. Actually fiber is mostly absent in processed and fast foods, because fiber falls apart when frozen unless you add stabilizing preservatives. Why is sugar not even on the food pyramid? Americans have no idea how much is dangerous, and frankly most doctors don't know either. The USDA and FDA are really behind the curve on this issue, possibly due to political pressure from the agri-business and food lobbies. The last FDA study on sugar was in 1986, and basically gave it a pass. You probably wouldn't be surprised to know that the FDA administrator in charge of that study later went on to work for the Corn Refiners Association. The study proposed that a sugar consumption (beyond fruit/veggie intake) of less than 40 lbs/person/year is "safe", even though the average American consumption at the time was 75. Now we're up to 90+. But the study didn't say what happens to people at those levels.

Yes, sugar products are pleasurable to consume, and they make most foods taste better (think baker's chocolate vs. milk chocolate, or medical electrolyte solution vs. Gatorade). But it's scary that one 12 oz. Coke contains 39 g of sugars. A typical mouse weighs 25 g. Now convert that to # of tablespoons in your head, and it's a scary picture.

It's one thing to know that sugars are bad, but it's another to stop people from harming themselves with it. Children, with very low impulse control, are abusing sugars and are the group with the highest surge of cardio diseases vs. their historical peers. That's partly why Michelle Obama and others are trying to get parents and schools to reduce their kids' exposure to junk foods. Maybe at some point we will need to implement a "fat and sugar tax", which would raise the prices on these dangerous foods in order to partly cover the social costs of consumers' future health problems. Heck we could even use some of those revenues to subsidize healthier, better foods for the poor, who are the model customers for bad foods because they are less educated in nutrition, and more likely to rely on cheap, fast food for survival.

But then you get the pro-business backlash and the conservative criticisms that gov't is trying to "run your life". People should be free to eat what they want! Even if it puts all of us at risk? The recent threat of a gov't shutdown, and our current debate about raising the federal debt limit, should remind us about the consequences of wasting money on preventable problems. Plus, the gov't already regulates other ingestibles like drugs, tobacco, and alcohol. The costs of abusing those products is arguable smaller than fat/sugar abuse. But it's so easy for these discussions to degenerate into culture war fodder (like climate change), instead of keeping it science and public policy based.

Other peoples, who traditionally consume very different diets than ours, are recently getting exposed to Western high-fat/sugar foods due to globalized food commerce. Fast food consumption in the West is leveling out, so firms are trying to tap new markets, often with great success. Inuits in northern Canada, who have survived on fish and marine mammals for millennia, are now getting Burger Kings in their villages. They're thrilled to eat such good-tasting, affordable food that doesn't need to be caught and hunted, but now their incidence of diabetes is going from near zero to through the roof. The same happened with some Pacific Islanders in the 20th Century.

http://www.npr.org/2011/03/24/132745785/how-western-diets-are-making-the-world-sick

Close to some of us, UCSF + the city of Martinez are experimenting with being sugar-free for a year (I couldn't find any web links about it though). This is ironic because a C&H Sugar plant is down the road from them in Crockett. I can imagine the findings will be quite noteworthy.

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I heard about this while back. But since everything is better in
moderation, better yet anything is bad for you if you over do it, then
everything (not just sugar) can be considered poisonous no? Surely we
can't label everything poisonous just because people can exercise
"moderation". Stick to the dictionary definition. Poison is something
that is harmful in all dose, not something we normally need as a food
group but now can be harmful because some gluttonous people over eat
themselves to self harm and destruction

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Well, this doctor is saying high fructose corn syrup (HFCS) in particular is bad for you no matter the dose. The body doesn't gain anything from it, and it only leads to increased triglyceride formation and insulin resistance. Maybe just having one Coke per month, you won't see a change in your health, but every little bit is making a small difference for the worst. So by that definition, HFCS is a poison. Natural fructose is a little different, because it exists in fresh foods with counter-balancing good nutritional properties. So maybe eating an apple is a net gain, even if it contains a small amount of "poisonous" fructose.

Some foods contain formaldehyde, iodine, etc. which are things that can be toxic at high doses, or can be good at low doses. If food labels would educate people on how much sugar becomes dangerous (depending on body weight, age, metabolism, etc.), then maybe consumers could make better decisions. But the problem is more economics than medicine. Our food industry has made sugar cheap and ubiquitous. And biologically, it is pleasurable and addictive like nicotine. So that is a dangerous combination. If we just let diabetic and hypertension people die, no problem. But we're pouring billions into their care, which is often preventable with different life choices. We force people to wear seatbelts and not talk on cell in the car to reduce the risk of harm, and if they violate we fine them. So we can tax booze, smokes, and maybe sugar. People can still eat it if they want, but they have to pay more to help cover the costs of the social harm. I guess it's the same idea as raising the costs of water on those who waste it.

I doubt any of this would happen, but we would have a healthier, more stable society if we did.

---------

article did not mention the word 'inflammation' even once.
metabolism discussion only.
nothing of the true disease cause... not all caused by sugar metabolism in host tissues
boo.

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Yeah, I mean he is on the extreme sugar fringe on the obesity-diabetes debate in order to shock people and draw more attention to sugar (that has a more positive perception in society than fat). He has plenty of detractors, but since the article/interview was meant for the general public, maybe he didn't want to get into too much inflammation and metabolic pathway science.

But his basic argument is (my interpretation at least, since I am not well versed in these matters):

-Natural fructose is more tolerable because it is found in high-fiber fruits that counter-balance the harms.
-Calories are not equal, and 100 cal of glucose intake is less harmful than 100 cal of fructose.
-Animal studies show sugar is addictive, and increases triglyceride production and insulin resistance.
-High-fructose corn syrup is more harmful than other forms of sugar.

Sunday, April 17, 2011

Update on fracking and water use

http://green.blogs.nytimes.com/2011/01/25/industry-boos-oscar-nod-for-gasland/
http://news.yahoo.com/s/ap/20110225/ap_en_ot/us_oscars_gasland

If you recall this email a while back, the "Gasland" film I reviewed was nominated for Best Documentary Oscar of 2010. Of course prior to the awards ceremony, a gas drilling industry trade group petitioned the MPAA to decertify the film as propaganda instead of documentary. Similar industry protests were made over "Sicko" and "An Inconvenient Truth". But probably the criticism only served to increase attention for the film, and the MPAA responded to the gas industry saying that they should "trust the intelligence" of the judges to know a documentary when they see it, and tell fact from fiction. While the film of course has an agenda, and some scenes are poorly executed and open to criticism, it was director Josh Fox's first film (made on quite a low budget as well), so to be nominated for the highest award in all of film-making must mean his argument has some merit. 

http://news.yahoo.com/s/ap/us_drilling_chemicals

Here is some validation for Fox's claims: 3 Congressmen released a report investigating 14 gas companies and the secret chemical mixtures they use during fracking. They said that millions of gallons of fracking fluid, containing up to 29 known or suspected carcinogens, were pumped into wells during domestic drilling from 2005-2009, with very little of that material recaptured by the drillers. So we can only conclude that the rest of it still remains in the ground, possibly leeching into aquifers that humans, wildlife, and livestock depend on. So how could these poisons, many of which are prohibited or on a "watch list" under the Clean Air/Water Acts, be covertly used in unregulated drilling? Congress granted drillers a waiver.

Methanol was the most common questionable substance used in fracking, and this is what it can do to you: http://www.epa.gov/chemfact/f_methan.txt. In my lab, I can lose my bonus or be fired for dumping even an ounce of methanol down the sink that drains to the Bay (not to mention my company getting fined), yet gas companies can get away with pumping untold gallons of it straight into the ground? And if the process is so safe as they claim, why be so secretive about their use of methanol and other poisons?

This may also be of interest to you, kind of an update on the status of drinking water:

http://www.npr.org/2011/04/11/135241362/the-worldwide-thirst-for-clean-drinking-water
http://www.treehugger.com/files/2009/06/we-use-how-much-water.php

Americans per capita consume 100 gallons of potable water each day from our daily activities (over 2X the global average, and 3X more than the average Chinese). That is pretty obscene, but when you factor in the water used in electricity generation for our energy needs, our consumption rises to 350 gallons/day. So cutting back on energy use is a win-win-win proposition, saving multiple precious resources and reducing pollution/environmental degradation/dependence on foreign oil dictators. Also adopting a vegetarian diet (avoiding beef consumption especially, since 2,400 L goes into making 1 burger patty) can dramatically reduce one's water footprint. Indian society would collapse if their people had American diets (30% of India is vegetarian). While India and China's per capita consumption is low, their massive populations are putting huge strains on their precarious water supplies (and climate change, standard of living improvements, and population growth will only make the situation worse in the future).

We wouldn't expect it, but leisure cities in Republican states are leading the way for water conservation. Las Vegas and Orlando have some of the most modern and strict water conservation policies, really because they have no choice (Las Vegas is the driest metro area in America with 4" of annual rainfall, and there have been recent severe droughts in the US Southeast). Those cities are known for water waste from golf courses and entertainment, and it's true that their economies still depend on those industries. But Orlando set up a parallel reclaimed water system, where household waste water is treated to near-potable safety levels, and then pumped out to water golf courses and sports fields, since it really makes no sense to waste drinking water on grass. Vegas pays residents to change out their lawns for desert landscaping, and issues huge fines for water overages, especially at golf courses. Therefore, golf courses now adopt drip irrigation for each individual shrub and putting green, instead of the usual wasteful area sprinklers. So even though Vegas has grown in population by 50% since 2000, their overall water consumption is flat, and actually down from 1990 levels. Imagine if progressive California could do that, but then we have the farm lobby, and suburbanites don't want their streets ripped up to lay new and better pipe. Plumbing is of great concern, since a scary amount of clean water (1/6 of total consumption) is lost from leaky pipes and toilets each day.

The author's #1 water concern for the future: corporate control of potable water.

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The problem with leaky pipes, etc is there is no good/easy way to detect a leak.  The only way for me as a homeowner to determine if i have a leaky anything that isn't a faucet is to either eventually notice some damage (which means the leak is either quite severe and/or in the drywall) or turn off my entire water supply and come back some undetermined amount of time later t see if the water meter moved.  If my water company put an ethernet output from the water meter and i could log in, take the output from excel or something, man it would be easy to check for leaky water or to see exactly how much water i use on sprinklers (since i generally am not using water at 4am), etc.  Those tools just aren't available for whatever reason.  

Imagine how easy it would be to conserve (or not to) if you knew in real dollars what every toilet flush cost your or how much water you wasted leaving the faucet on while you brushed your teeth.

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Yeah seriously, I guess we should get in with Bechtel or Schlumberger exploiting some water-starved third world hole: http://www.corpwatch.org/article.php?id=6670

I agree about leak detection. Like that author said, our water system is really 50-100 years old. We take water for granted, and barely commit any resources for maintenance and monitoring. I think he said in his city of Chicago, they schedule pipe replacement at a 160-year rate (meaning they do it so slowly, it would take that long to replace the whole system).

I agree that costs for water, gas, beef, etc. need to better align with the true social costs, but of course companies don't want to acknowledge the externalities associated with their products. Since clean water is a vital resource, I think everyone should have the "right" to access a minimal amount of it, so I wouldn't just advocate an across-the-board rate hike. If we invested in a better monitoring system, each citizen/farm/company could get an adjusted quota of X gallons/month, charged a reasonable rate. For those who exceed the quota, they would pay through the nose. So we would still be free to consume more water if it was that important to us (for watering the lawn, swimming pool, etc.), but the price would reflect the social harm we are doing.

Industry and farming use much more water than households. So this would force farmers to switch leaner irrigation and companies to adopt less water-intensive operations. It might reduce the diversity of available produce at Safeway, or increase the costs of some goods, but we're talking about survival here. And the $ the gov't collects from water overages could then be invested into water research or subsidies to reward people/farms/firms for buying water sparing tech or improving their pipes. Like Orlando, we have to implement a parallel reclaimed water system. Factories, golf courses, etc. shouldn't be allowed to use fresh/clean/reservoir water. All this would require a huge investment to set up, but down the road it could pay for itself.

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Of course any extra fees gotten by the gov would invariably be used for something besides improving water efficiency.  When social security runs surplus, does social security get reinvested?  When the budget surplus happened under clinton, did the debt get paid down?  A problem but i suppose a good one to have.
I feel like water is a lot like oil in the sense that no one is going to sweat it until they can't get it.  Unlike oil i've only got ~ 3 days to figure out how to get it or I die.  But no one is going to pay meaningful attention to the problem until it is too late. Perhaps a fundamental human flaw and perhaps just an institutional problem, either way if we aren't in trouble our children or our children's children will be. 

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Yes, you are right about inflows of cash to the gov't. But at least higher prices will encourage people to use less. It is true that water and oil management are quite similar. I guess since the Cold War, this is the first time that humanity has had to pay for water. Of course we get a clean, virtually limitless supply of water in our homes and businesses, and that costs something. But humans are not used to seeing water as a commodity. Imagine if it was trading on some exchange like gold and pork!

I think due to globalization, wealth is increasing in a lot of previously poor places, and those people will want better standards of living. We already see this effect with energy (and food to some degree), but soon it will be clean water. But as you said, no one wants to confront the problem until it's too late. Actually I would expect China to be the most proactive due to their centralized gov't. They are transitioning to a less carbon-intensive economy faster than any other nation. It's not like China is a poster child for Greenpeace, but hopefully they can enact smart water management that we in the West could also copy (if Congress ever does anything).

Friday, April 8, 2011

Threat of gov't shutdown

http://news.yahoo.com/s/ap/ap_on_re_us/us_spending_showdown

Let me see if I get this straight: the House GOP threatened to shut the gov't down unless the Dems agreed to their draconian spending cuts (keep tax breaks for the rich - because that creates jobs of course, keep the military rolling, but cut aid for the poor and other liberal junk). The Dems compromised on like 90% of their demands last week, but still they didn't budge an inch. Their political posturing and theatrics took the country to the brink, despite a last-minute deal. As of a few hours ago, a shutdown appeared so likely that much of the gov't worked overtime this week to get millions of furlough notices drafted and plans in place to close down or seek alternative funding.

So in these uncertain, stressful times, just think of all the man-hours of lost productivity spent preparing for a looming shutdown that fortunately didn't materialize (not to mention the anxiety and distraction of worrying about it). If this budget battle was supposedly about cutting spending from the get-go, imagine all the millions of dollars wasted by our gov't agencies, because they had no choice but to prepare two action plans depending on what Washington did today.

If the GOP really cares about reducing the deficit, they have a funny way of showing it by engaging in totally unnecessary, reckless behavior that only caused more waste. They could have gotten their spending cuts days ago, without pulling this expensive, shameful poker bluff bitch-move on America, just so they could placate their base that they "worked down to the wire" to de-fund Planned Parenthood and de-claw the EPA. But they don't feel the externalities of their actions, so they don't care. They scared the crap out of millions of Americans who depend on a gov't paycheck or services. But why should we expect them to understand? The median net worth of Congress is over $800K, while overall US median household worth is $96K (that figure is down 23% since 2006, due to the recent recession mostly caused by Washington de-regulation and their Wall Street pals' excesses).

http://www.gobankingrates.com/savings-account/us-family-net-worth-drops-23-percent-during-recession/
http://www.opensecrets.org/news/2009/01/wealthy-freshmen-raise-congres.html